Late-breaking abstracts on clinical trials and scientific breakthroughs

The ERS Congress is the place to be for the unveiling of the latest and most important/impactful clinical trials in the field of respiratory medicine.

*Note: Click on the session title for details of time, date, location and session type.

Session title

Featuring late-breaking abstracts (clinical trials) on the topic of
Advanced profiling of immune cells in chronic lung diseases Intra-alveolar neutrophil-derived microvesicles: a biomarker of COPD severity

Elevated airway lymphocytes in adults born prematurely with a history of bronchopulmonary dysplasia

Biomarkers of COPD Long-term variability of blood eosinophils in COPD patients by GOLD 2017 staging, and gender bias
Chronic respiratory disease: respiratory muscle function, breathing exercises and airway clearance techniques Primary care providers' fidelity to a brief asthma shared decision-making intervention
Clinical and functional monitoring in airway disease Effect on asthma control using a novel digital self-management system: a physician blinded randomised controlled cross-over pilot trial
Clinical news in idiopathic interstitial pneumonias Prevalence and clinical significance of antinuclear antibody (ANA) in IPF: analysis from ESTAIR study
Clinical trials in COPD: new results Azithromycin for acute COPD exacerbations requiring hospitalization – the BACE trial results
COPD: from LABA/ICS to LABA/LAMA/ICS Blood eosinophil counts and treatment response in COPD: analyses of IMPACT

IMPACT study — single inhaler triple therapy (FF/UMEC/VI) versus FF/VI and UMEC/VI in patients with COPD: healthcare resource utilization and costs — UK

Analysis of the InforMing the PAthway of COPD Treatment (IMPACT) study in the subgroup of patients taking triple therapy at screening

Reduction of COPD exacerbations with extrafine single inhaler triple therapy: post-hoc analysis by exacerbation treatment of the TRIBUTE study

Extrafine single inhaler triple therapy improves quality of life in COPD. Analysis of SGRQ subdomains of the TRIBUTE Study

Determinants of COPD morbidity and exacerbations Safety and immunogenicity of non-typeable H. influenzae (NTHi) and M. catarrhalis (Mcat) adjuvanted vaccines in adults

Safety and immunogenicity of non-typeable H. influenzae (NTHi) adjuvanted vaccine in older adults with chronic obstructive pulmonary disease (COPD)

Functional assessment of COPD Combined Use of Inspiratory and Expiratory Threshold Pressure Training with Data Monitor in COPD

Dietary nitrate supplementation enhances the benefit of pulmonary rehabilitation in people with COPD

Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen

General thoracic surgery Pre-operative Non Invasive Ventilation (NIV) does not decrease post-operative complication rate after carcinologic lung surgery: the preOVNI GFPC 12-01 randomized controlled study.
Genetics in chronic pulmonary diseases Endobronchial gene-expression clustering in COPD identifies a subgroup with higher level of lymphocytes and accelerated lung function decline
ILDs: From bench to bedside Phase 1 dose escalation study of aerosolized pirfenidone in normal healthy volunteers (NHV), smokers, and IPF patients
Integrated care and non-pharmacological management of COPD Impact of eosinophil levels on lung function and exacerbation benefits with co-suspension delivery technology budesonide/glycopyrronium/formoterol metered dose inhaler (BGF MDI) in COPD (KRONOS study subgroup analysis)
Integrating pharmacological and non-pharmacological management in COPD: are we there yet? A randomized clinical study to assess the impact of budesonide/formoterol (BUD/FM) pMDI medication reminders on adherence in COPD patients
Interventional pulmonology highlights in 2018: latest innovations First-in-Human Results of Bronchial Rheoplasty: An Endobronchial Treatment For Chronic Bronchitis (CB)
Latest advances in pulmonary rehabilitation assessment and content A cluster-randomized trial of a nurse-led advance care planning session in patients with COPD and their loved ones
Muscle adaptations in response to physiotherapeutic interventions in acute and chronic settings Carnosine and related compounds in m. vastus lateralis of COPD patients: preliminary results
New methods and concepts in exercise testing Conversion of FENO: from different flows to the standard flow
New pharmacological strategies in airway diseases Explore the effective dose of bronchodilator nebulization via high flow nasal cannula in adult COPD and asthma patients
New predictors of morbidity and mortality in COPD High-sensitivity troponin I predicts all-cause mortality in stable COPD in the COSYCONET cohort
Notable Studies in Asthma Which treatable traits matter? Prevalence of treatable traits and risk of exacerbation in a random population sample with asthma

Long-term safety and efficacy of benralizumab in severe, uncontrolled asthma: first results of BORA, a randomized, Phase III extension study

Long-term safety & durability of mepolizumab in life-threatening/seriously debilitating severe eosinophilic asthma (SEA): COSMEX

Novel drug targets for asthma and COPD RPL554, a first-in-class dual PDE3/4 inhibitor, causes significant bronchodilation and symptom relief; a Phase 2b COPD study
Paediatric asthma: new mechanisms and tools Tidal breathing variability during sleep is a sensitive marker of disease control in small children with recurrent wheeze
Primary care management of respiratory conditions Trial of c-reactive protein point of care testing (CRP-POCT) for safely reducing antibiotics for acute exacerbations of chronic obstructive pulmonary disease (COPD) in primary care
Risk stratification in treatment of pulmonary arterial hypertension Efficacy and safety of macitentan in portopulmonary hypertension: the PORTICO trial
What is new in idiopathic interstitial pneumonias? Phase 1, first-in-human study of OATD-01, a dual chitinase inhibitor for the treatment of respiratory diseases
What's new in lung function and exercise assessment in COPD? Comparison of High Flow Nasal Cannula with Noninvasive Ventilation in Facilitating Weaning COPD From Invasive Ventilation: A Prospective Randomized Controlled Study

Effect of oxygen supplementation on sleep and nocturnal breathing in patients with chronic obstructive pulmonary disease travelling to high altitude: randomized trial

Variant forms of asthmaariant forms of asthma Risk of a severe exacerbation following higher reliever use: post-hoc analysis of SYGMA 1 in mild asthma